首页|泛癌分析揭示SREK1在低级别胶质瘤中促进CD274表达

泛癌分析揭示SREK1在低级别胶质瘤中促进CD274表达

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目的 剪接调节谷氨酸和富赖氨酸的蛋白质1(SREK1)在多种肿瘤中的泛癌分析,揭示SREK1在泛癌中的作用.方法 利用在线数据库GEPIA 2、TIMER 2.0、TISIDB和cBioPortal分析SREK1表达对肿瘤患者预后的影响、在低级别胶质瘤(LGG)肿瘤组织中的表达、遗传变异的特征及其表达对肿瘤组织中免疫细胞的浸润和免疫—肿瘤靶基因的相关性分析.结果 LGG肿瘤组织中,SREK1表达与记忆B细胞、活化的CD4+T细胞、Th2细胞、中性粒细胞、NKT细胞以及单核细胞和CD56dimNK细胞的浸润存在相关性(P均＜0.05).SREK1与免疫—肿瘤靶基因如信号传导及转录激活蛋白3(STAT3)、Ⅰ型干扰素受体1(IFNAR1)、核受体亚家族3C组成员1(NR3C1)和表皮生长因子受体(EGFR)、表面抗原分化簇274(CD274)等表达在LGG中均呈正相关(P均＜0.05).结论 SREK1是LGG患者的危险因子之一,可能通过促进CD274的表达来加剧LGG的进展.
Pan-cancer Analysis Revealed SREK1 Promotes CD274 Expression in Low-grade Glioma
Objective To analyze the role and potential function of SREK1 in pan-cancer from TCGA via various bioinformatics.Methods GEPIA 2,TIMER 2.0,TISIDB and cBioPortal web server were used to analyze the effect of SREK1 expression on the prognosis of tumor patients,the expression of SREK1 in low-grade glioma(LGG)tumor tissues,the characteristics of genetic variation,and the correlation analysis of SREK1 expression on immune cell invasion in tumor tissues and immuno-oncology target genes.Results SREK1 expression had a strong relationship with the percent of B memory cells,CD4+T,Th2,neutrophils,NKT,monocytes and CD56dim NK cells in LGG(P all＜0.05).SREK1 had a strong positive correlation with immuno-oncology target genes,including singal transducer and activator of transcription 3(STAT3),Interferon alpha and beta receptor subunit 1(IFNAR1),nuclear receptor subfamily 3 group C member 1(NR3C1),epidermal growth factor receptor(EGFR),cluster of differentiation 274(CD274)(P all＜0.05).Conclusion SREK1 is a risk factor for LGG patients,and has a strong positive relationship with CD274.

splicing regulatory glutamic acid and lysine rich protein 1low-grade gliomaprogrammed cell death ligand 1interferon alpha and beta receptor subunit 1signal transducer and activator of transcription 3immuno-oncology target genes

刘东、刘媛、张淑灵、王玉祥

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宁夏医科大学创新创业学院,银川 750004

宁夏医科大学人文与管理学院,银川 750004

宁夏大学生命科学院,银川 750021

剪接调节谷氨酸和富赖氨酸的蛋白质1 低级别胶质瘤 细胞程序性死亡-配体1 Ⅰ型干扰素受体1 信号转导和转录激活因子3 免疫—肿瘤靶基因

宁夏自然科学基金项目

2023AAC03244

2024

10.16050/j.cnki.issn1674-6309.2024.09.005

宁夏医科大学学报
宁夏医科大学

宁夏医科大学学报

CSTPCD
影响因子：0.84
ISSN：1674-6309
年,卷(期)：2024.46(9)