Objective To analyze the role and potential function of SREK1 in pan-cancer from TCGA via various bioinformatics.Methods GEPIA 2,TIMER 2.0,TISIDB and cBioPortal web server were used to analyze the effect of SREK1 expression on the prognosis of tumor patients,the expression of SREK1 in low-grade glioma(LGG)tumor tissues,the characteristics of genetic variation,and the correlation analysis of SREK1 expression on immune cell invasion in tumor tissues and immuno-oncology target genes.Results SREK1 expression had a strong relationship with the percent of B memory cells,CD4+T,Th2,neutrophils,NKT,monocytes and CD56dim NK cells in LGG(P all＜0.05).SREK1 had a strong positive correlation with immuno-oncology target genes,including singal transducer and activator of transcription 3(STAT3),Interferon alpha and beta receptor subunit 1(IFNAR1),nuclear receptor subfamily 3 group C member 1(NR3C1),epidermal growth factor receptor(EGFR),cluster of differentiation 274(CD274)(P all＜0.05).Conclusion SREK1 is a risk factor for LGG patients,and has a strong positive relationship with CD274.
splicing regulatory glutamic acid and lysine rich protein 1/low-grade glioma/programmed cell death ligand 1/interferon alpha and beta receptor subunit 1/signal transducer and activator of transcription 3/immuno-oncology target genes
维普
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