Clinical and Pathological Characteristics and Prognostic Analysis of Stage Ⅰ Lung Invasive Adenocarcinoma
Objective To analyze the correlation between the clinicopathological characteristics and prognosis of patients with stage Ⅰ invasive lung adenocarcinoma,and to explore the risk factors affecting the prognosis of patients with stage Ⅰ invasive lung adenocarcinoma.Methods Patients were pathologically diagnosed with stage Ⅰ invasive lung adenocarcinoma after surgery were included.Follow-up was carried out by reviewing the records of follow-up visits or via telephone,with the starting point being the date of the patient's surgery and concluding on September 1,2022.A retrospective analysis was performed on their clinical data,pathological data,and prognostic information.Results Among the 203 patients,81 were males and 122 were females,with a male-to-female ratio of 1∶1.51,the average age was(59.49±9.12)ages.The 1-and 2-year progression-free survival rates were 96.55％and 92.12％,respectively,While the 1-and 2-year overall survival rates were 99.51％and 99.01％,respectively.Univariate analysis showed that female gender,stage Ⅰ B,the presence of high-grade components,and postoperative adjuvant therapy were related to postoperative PFS,the presence of high-grade components,sublobar resection,and postoperative adjuvant therapy were related to postoperative OS(P all＜0.05);Multivariate analysis indicated that male gender and the presence of high-grade structures were independent risk factors for reduced postoperative PFS(P all＜0.05);sublobar resection and the presence of high-grade structures were independent risk factors for reduced postoperative OS(P all＜0.05).Conclusion The presence of high-grade components is an independent risk factor for increased risk of postoperative recurrence and lung cancer-related mortality in patients with stage Ⅰ invasive adenocarcinoma.
lung canceradenocarcinoma of lungprognosisoverall survivalprogression-free survival
万方数据
维普
