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喉癌患者预后相关因素分析

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目的 分析喉癌患者的临床特点及其对预后的影响,为喉癌患者治疗方案的选择及预后的判断提供依据.方法 选取2011年1月至2017年12月在宁夏医科大学总医院住院并接受治疗的222例喉癌患者为研究对象,收集患者一般情况、病理分期、临床分期、手术方式、综合治疗生存情况等,用Kaplan-Meier法及Cox回归模型进行生存分析.结果 222例喉癌患者第1、3、5、7年的生存率分别为93.1%、84.8%、70.4%、63.6%.不同年龄、临床分期及手术方式喉癌患者的生存率差异均有统计学意义(P均<0.05).Cox回归模型分析显示,对生存有影响的因素包括年龄(RR=3.448,P<0.001)和临床分期(RR=0.302,P=0.004).结论 年龄、临床分期对喉癌患者的生存预后有影响,在治疗中应依据多种因素进行综合评估并选择个性化治疗.
Analysis of Related Factors Affecting Prognosis of Laryngeal Cancer Patients
Objective To analyze the prognostic factors of laryngeal cancer,and to provide evidence for the selection and improvement of treatment and prognosis of laryngeal cancer patients.Methods 222 cases of laryngeal cancer hospitalized and treated in General Hospital of Ningxia Medical University from January 201 1 to December 2017 were confirmed by electronic laryngoscope,neck enhanced CT and pathological biopsy before surgery.Data were collected to record the patients general condition,pathological stage,clinical stage and surgical method.Kaplan-Meier method and Cox regression model were used for survival analysis.Results The 1,3,5 and 7-year survival rates of 222 patients with laryngeal cancer were 93.1%,84.8%,70.4%and 63.6%,respectively.There were statistically significant differences in survival rates among patients with laryngeal cancer of different ages,clinical stages,and surgical methods(P all<0.05).Cox regression model analysis showed that factors affected survival including age(RR=3.448,P<0.001)and clinical stage(RR=0.302,P=0.004).Conclusion Age and clinical staging have an impact on the survival prognosis of laryngeal cancer patients,and personalized treatment should be selected based on a comprehensive evaluation of multiple factors during treatment.

laryngeal carcinomasurvival analysisoperationprognosis

李霞、曹玲、王志婕、穆建梅、侯丽、刘静

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银川市第三人民医院,银川 750021

宁夏医科大学总医院耳鼻咽喉头颈外科,宁夏医科大学第一临床医学院,银川 750004

喉癌 生存分析 手术 预后

宁夏自然科学基金项目宁夏医科大学校级课题

2020AAC03493xm2019-175

2024

宁夏医科大学学报
宁夏医科大学

宁夏医科大学学报

CSTPCD
影响因子:0.84
ISSN:1674-6309
年,卷(期):2024.46(9)