Effect of St.John's Wort Extract Combined with Vestibular Rehabilitation Therapy for Residual Dizziness after Successful Reduction of Benign Paroxysmal Positional Vertigo
Objective To discuss the efficacy and possible related factors of St.John's wort extract combined with vestibular rehabilitation therapy(VRT)after successful reduction of residual dizziness(RD)in patients with BPPV.Methods Patients with RD symptoms diagnosed with BPPV and successful manual reduction were randomly divided into observation group and control group.Observation group was treated with St.John's wort extract combined with VRT and control group was treated with VRT.The improvement of dizziness,disability,anxiety and depression of patients in the two groups was compared.Results There were 252 cases(50.4％)of RD patients after successful reduction in 500 cases of BPPV.Disability Scale in the observation and control groups after 2 weeks of treatment(dizziness handicap inventory,DHI)grade,Included emotions(emotional,DHI-E),function(functional,DHI-F),soma(physical,DHI-P)and vertigo disability scale total(DHI-T)scores decreased significantly compared with before treatment(P all＜0.01).However,the observation group was lower than the control group(P all＜0.01).The screening scale of depression(PHQ-9)and anxiety screening scale(GAD-7)scores decreased in both groups(P all＜0.01),but the observed group was more significant than the control group(P＜0.001).Two cases had dry mouth symptoms in the observation group,and the symptoms disappeared after drug withdrawal,and no adverse reactions occurred in the control group.Conclusion St.John's wort extract combined with VRT for RD after successful redultion of BPPV can reduce dizziness symptoms,depression and anxiety,with few adverse reactions.
万方数据
维普
