Risk Factors Analysis of Extrauterine Growth Retardation in Preterm Infants with Gestational Age Less than 34 Weeks
Objective To analyze the risk factors of extrauterine growth retardation in preterm infants with gestational age less than 34 weeks.Methods The subjects were selected from July 2022 to June 2023 in the neonatal intensive care unit at Yinchuan Women and Children Healthcare Hospital with a gestational age of less than 34 weeks which were premature and suitable for gestational age.According to the Fenton Growth Curves for Preterm Infants(2013 Edition),the 10 th percentile of premature infants whose body weight was lower than the average growth parameters of the same gestational age at discharge or the corrected gestational age of 36 weeks included in the extrauterine growth retardation group(EUGR,n=44)and the non-EUGR group(n=61).The two groups'general condition,treatment,complications,and mother-related clinical indexes were collected and analyzed by SPSS 25.0 statistical software.Logistic regression was used to analyze the risk factors of EUGR in premature infants.Results The incidences of blood transfusion ≥2 times,as well as apnea,hemodynamically significant patent ductus arteriosus(hs-PDA),and bronchopulmonary dysplasia(BPD)in the EUGR group were higher than those in the non-EUGR group(P all＜0.05).In contrast,the birth weight and the average calorie intake in the first week of admission in the EUGR group were lower than those of the non-EUGR group(P all＜0.05).The non-invasive ventilation time,total oxygen inhalation time,total fasting time,total gastrointestinal feeding time,parenteral nutrition(PN)duration,starting breast milk fortifier time,antibiotic use time and hospital stay in the non-EUGR group were higher than those in the non-EUGR group.There were no significant differences in hyperglycemia,hypoglycemia,necrotizing enterocolitis(NEC),retinopathy of prematurity(ROP),intracranial hemorrhage(IVH),neonatal respiratory distress syndrome(NRDS),early-onset septicemia(EOS),late-onset septicemia(LOS),starting time of parenteral nutrition(PN),average calorie of the second week,postnatal age,gestational week,invasive ventilation time,starting feeding time,recovery time to birth weight,time of invasive ventilation,the duration of complete reinforcement of breast milk fortifier,the degree of weight loss,the mode of delivery,multiple births,assisted reproduction,prenatal non-use of corticosteroids,nosocomial infection,gestational diabetes,pregnancy hypertension,maternal hypothyroidism,and maternal body mass index(Pall＞0.05).Logistic regression analysis showed that birth weight(OR=0.993,95％CI:0.989-0.997)and total fasting time(OR=1.025,95％CI:1.001-1.050)were independent risk factors for EUGR in premature infants and delayed human milk fortifier time(OR=1.255,95％CI:1.064-1.480)in EUGR premature infants.Conclusion For preterm infants with gestational age less than 34 weeks,birth weight and long fasting time are the independent risk factors,and breast milk fortifier for premature infants with EUGR is delayed.
premature infantsappropriate for gestational ageextrauterine growth retardationrisk factors
万方数据
维普
