Expression of AMH and Its Receptor in Endometrium of Patients with Repeated Implantation Failure
Objective To investigate the correlation between AMH and its receptor(AMHR Ⅱ)with repeated implantation failure.Methods Thirty patients who underwent IVF-ET and experienced repeated implantation failure were selected as the experimental group,and 30 patients with clinical pregnancy after the first cycle of fresh embryo transfer were chosen as the control group.RT-qPCR was used to detect the expression levels of AMH and AMHR Ⅱ mRNA in endometrium of each group.Western blot was used to detect the expression levels of AMH and AMHR Ⅱ protein in endometrium of each group.Results The expression levels of AMH mRNA and protein in endometrium of RIF group were higher than those of control group(P＜0.05);the expression levels of AMHR Ⅱ mRNA and protein in endometrium of RIF group were higher than those of control group(P＜0.05).Conclusion AMH and its receptor may be correlated with the occurrence of repeated implantation failure.
anti-müllerian hormoneanti-müllerian hormone type Ⅱ receptorrepeated implantation failureendometrial receptivity
万方数据
维普
