Expression and clinical significance of IL-6,STAT3 and Cyclin D1 in colorectal adenocarcinoma
Objective To study the expression and correlation of interleukin 6(IL-6),signal transduction and activator of tran-scription 3(STAT3)and cyclin D1(Cyclin D1)in colorectal adenocarcinoma and adjacent tissues,and to analyze its relationship with clinical pathological characteristics and prognosis of patients.Methods The expression levels of IL-6,STAT3 and Cyclin D1 were detec-ted by using immunohistochemical staining in 80 cases of colorectal adenocarcinoma and paracancerous tissues.The correlation of their ex-pressions and their relationship with clinicopathological features and prognosis were analyzed and the results were verified by biological da-tabase.Results The positive expression rates of IL-6,STAT3 and Cyclin D1 expression in colorectal adenocarcinoma tissues were respec-tively 53.8％,63.8％,62.5％and the positive rates of IL-6,STAT3 and Cyclin D1 expression in adjacent tissues were respectively 32.5％,25％,15％(P＜0.05).The expression of IL-6 and STAT3 in colorectal adenocarcinoma tissue was positively correlated(P＜0.05),the expression of STAT3 and Cyclin D1 was positively correlated(P＜0.05).STAT3 was related to lymph node metastasis and clin-ical stage(P＜0.05),and Cyclin D1 was closely related to depth of invasion,lymph node metastasis and clinical stage(P＜0.05).It showed that the degree of differentiation,depth of invasion,lymph node metastasis,clinical staging,Cyclin D1 were factors affecting the prog-nosis of patients with colorectal adenocarcinoma after surgery(P＜0.05).It showed that the degree of differentiation and Cyclin D1 were in-dependent risk factors for postoperative prognosis of colorectal adenocarcinoma patients(P＜0.05).Conclusion IL-6,STAT3 and Cyclin D1 are overexpressed in colorectal adenocarcinoma.Cyclin D1 is an independent risk factor for postoperative prognosis of colorectal adeno-carcinoma,and it can be used as an indicator to evaluate the clinical progress and prognosis of patients with colorectal adenocarcinoma.
万方数据
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