Association between high-risk HPV genotype subtype infection and cervical lesions
Objective To analyze the association between high-risk human papillomavirus(HR-HPV)genotype infection and cervical lesions.Methods A total of 872 patients with cervical lesions who met the criteria for HPV typing and biopsy were se-lected.The HPV typing and biopsy,the occurrence and distribution of HR-HPV single infection type,multiple mixed infection type,number of subtypes and cervical lesions were analyzed.Results Among the 872 patients with cervical lesions who met the criteria were included in the study,597 cases(68.46％)were single-infected,and the five genotypes with the highest detection were 16,52,58,18(33),31,and the top five high-risk subtypes were 16,52,58,53 and 59 in the cervicitis group.The top five high-risk subtypes detec-ted in the CIN 1 group were 16,58,52,18 and 31,and the top five high-risk subtypes detected in the CIN 2 and CIN 3 groups were 16,52,58,and 33,18,cervical cancer group was mainly 16 types,followed by 33 types,HPV16 type with the aggravation of lesion in a single infection,the infection rate increased significantly,the difference was statistically significant(P＜0.05).There were 275 cases(31.54％)of multiple infection,and the five genotypes with the highest detection were 16,52,58,18 and 53,among which the top five high-risk subtypes detected in the cervicitis group were 58,52,16,53,18,the first five high-risk subtypes detected in the CIN 1 group were 16,52,58,53,and 51;the top five high-risk subtypes detected in the CIN 2 and CIN 3 groups were 16,52,58,18,33,and the cervical cancer group was mainly 16 types.It was followed by type 18,HPV16 type increased significantly with the aggravation of lesion degree in multiple infections(P＜0.05).Conclusion The top three types with the highest detection of single infection and multiple infection are 16,52 and 58,among which the detection rate of HPV16 type is positively correlated with the degree of lesions,and the sin-gle infection is higher than that of mixed infection in different cervical lesions.
万方数据
维普
