Application of serum endocrine hormones combined with HE4,CA125,and AFP detection in the clinical diagnosis of cervical cancer
Objective To investigate the clinical value of serum endocrine hormone combined with human epoetin 4(HE4),glycoantigen 125(CA125),and alpha-fetoprotein(AFP)testing in patients with cervical cancer.Methods 80 patients with cervical cancer were selected as the malignant group and 80 patients with cervical intraepithelial neoplasia as the benign group.The levels of ser-um HE4,CA125,AFP,folliculopoietin(FSH),luteinizing hormone(LH),estrogen(E2)were compared between two groups,and the correlation between serum HE4,CA125,AFP and FSH,LH,E2 was analyzed.The optimal cut-off value was used to analyze the influ-ence of each serum index.Influence of cervical cancer development risk of each serum index was analyzed by comparing the levels of ser-um FSH,LH,E2,HE4,CA125 and AFP in patients with different pathological characteristics in the malignant group.Results Serum FSH,LH,E2,HE4,CA125 and AFP levels were higher in the malignant group than those in the benign group(P＜0.05).Serum FSH,LH,E2,HE4,CA125 and AFP levels were higher in patients with tumor diameter ≥4 cm,clinical stage Ⅲ～Ⅳ,low degree of differentia-tion and lymph node metastasis than those in patients with tumor diameter＜4 cm,clinical stage Ⅰ-Ⅱ,medium to high degree of differen-tiation and no lymph node metastasis,respectively(P＜0.05).Serum HE4,CA125 and AFP were positively correlated with FSH,LH and E2(P＜0.05).The area under curve(AUC)for the combined diagnosis of cervical cancer with serum FSH,LH,E2,HE4,CA125,and AFP were respectively 0.940(95％CI:0.892～0.972),with a Yordon index of 0.750,which was greater than the single diagnosis of each index;using the best cut-off value as the boundary,the risk of cervical cancer in patients with positive expression of serum FSH,LH,E2,HE4,CA125,and AFP were 2.612 times,1.976 times,2.829 times,3.305 times,3.566 times,and 3.492 times higher than those of patients with negative expression,respectively;serum FSH,LH,E2,HE4,CA125,and AFP were positively correlated with tumor diameter,clinical stage,and lymph node metastasis,and negatively correlated with the degree of differentiation(P＜0.05).Conclusion Serum FSH,LH and E2 are significantly correlated with HE4,CA125 and AFP in patients with cervical cancer,and the combined diagnostic value is more reliable and also provides data to support clinical assessment of disease progression.
Cervical cancerHuman epithelial protein 4Glycoantigen 125Aalpha-fetoproteinEndocrine hormoneCorrelationValue of combined assay
万方数据
维普
