Analysis on the risk and efficacy of intravenous thrombolysis for cognitive impairment in patients with cerebral infarction combined with white matter lesions
Objective To analyze the risk and efficacy of cognitive impairment after intravenous thrombolysis in patients with cerebral infarction combined with white matter lesions(WML).Methods Retrospective analysis of the clinical data of 220 patients with cerebral infarction and complicated with WML were treated for intravenous thrombolysis.According to the cognitive function after intrave-nous thrombolysis treatment,the patients were divided into the impaired group(n=53)and the non-impaired group(n=167).It was identified the risk factors that affect cognitive function in patients with cerebral infarction and WML after intravenous thrombolysis by u-sing multivariate logistic regression analysis.Results The age of patients in the obstacle group was ≥ 60 years old,the NIHSS score was≥9 points,the proportion of moderate to severe WML,and the serum AQP4 level were higher than those in the obstacle free group.The expression of miR-29b was lower than that in the obstacle free group,and the difference was statistically significant(P＜0.05).ROC curve analysis showed that serum miR-29b and AQP4 could predict the occurrence of cognitive impairment after cerebral infarction com-bined with WML thrombolysis treatment,with areas under the curves of 0.842 and 0.840,respectively(P＜0.05).It was showed that age ≥ 60 years old,moderate to severe WML,NIHSS score ≥ 9 points,miR-29b＜0.895,AOP4≥33.695 µg/L were risk factor for cognitive impairment after cerebral infarction combined with WML thrombolytic therapy.Conclusion Cognitive dysfunction after cere-bral infarction combined with WML intravenous thrombolysis is influenced by age,WML degree,NIHSS score,miR-29b expression lev-el,and AOP4 level.
Cerebral infarctionWhite matter lesions of the brainIntravenous thrombolysisCognitive function
万方数据
维普
