Expression of CXCL5 in platinum-resistant epithelial ovarian cancer tissue and its relationship with clinical features of patients
Objective To explore the relationship between the expression of CXC chemokine ligand-5(CXCL5)and clinical features in platinum-resistant epithelial ovarian cancer.Method 134 patients with epithelial ovarian cancer who received the tumor cell reduction surgery combined with platinum-based standard chemotherapy were collected.According to the recurrence rate of patients six months after stopping chemotherapy,they were divided into platinum resistant group(n=70)and platinum sensitive group(n=64).Immunohistochemistry was used to detect the expression of CXCL5 in ovarian cancer tissue,and its correlation with platinum resistance in epithelial ovarian cancer was analyzed.Result The expression of CXCL5 in platinum-resistant epithelial ovarian cancer was mainly lo-cated in the cytoplasm of cancer cells,and the expression level of CXCL5 in platinum-resistant ovarian cancer was significantly lower than that in platinum-sensitive ovarian cancer tissue(P＜0.05).The expression of CXCL5 in platinum-resistant epithelial ovarian cancer was significantly correlated with neoadjuvant chemotherapy,total chemotherapy times,HE4,NEUT,PLT,FIGO stages,histological differentiation and ascites,and negatively correlated with neoadjuvant chemotherapy,total chemotherapy times,HE4,FIGO stages and as-cites(P＜0.05).Among them,there were negative correlation with NEUT,PLT and histological differentiation.There was no significant correlation with CA125,age,menopausal state,lesion size,unilateral or bilateral tumor and vascular positive(P＞0.05).Conclusion The decreased expression of CXCL5 in platinum-resistant epithelial ovarian cancer tissue is related to neoadjuvant chemo-therapy,total chemotherapy times,HE4,NEUT,PLT,FIGO stage,histological differentiation and ascites.It is suggested that the low ex-pression of CXCL5 may be related to platinum resistance in epithelial ovarian cancer.
CXCL5Platinum resistanceEpithelial ovarian cancerClinical features
万方数据
维普
