Study on the treatment of hashimoto hypothyroidism by warming yang and strengthening spleen therapy combined with vitamin D regulate immune imbalance
Objective To observe the efficacy of warming yang and strengthening spleen method combined with vitamin D to regulate immune imbalance in the treatment of Hashimoto's thyroiditis(HT)combined with hypothyroidism.The clinical efficacy was al-so evaluated by detecting the percentage of Th17 and Treg cell expression before and after treatment in patients with HT hypothyroidism.Methods 64 cases of inpatient and outpatient were selected and randomly divided into control group and experimental group(with 32 cases in each group),the control group was given vitamin D,and the experimental group was given Fufang jiazhueping with vitamin D.The course of the treatment lasted for 8 weeks,and the efficacy of the traditional Chinese medicine(TCM)symptoms,serum thyroid stim-ulating hormone(TSH),free triiodothyronine(FT3),free thyroxine(FT4),thyroid peroxidase antibody(TPO-AB),thyroglobulin anti-body(TGAb),the percentage of expression of Th17 and Treg cells,and changes in the volume of the thyroid gland between the two groups were compared.Results The improvement of TCM symptom score before and after treatment was significantly better in the exper-imental group than that in the control group(P＜0.05).The efficacy of FT3,FT4,TSH levels,and thyroid volume were same between the two groups after treatment(P＞0.05).Comparison of thyroid antibody indexes between the two groups before and after treatment,the efficacy of the experimental group was better than that of the control group(P＜0.05).Conclusion The warming yang and strengthe-ning spleen method combined with vitamin D in the treatment of HT is safe with fewer adverse reactions,and deserves to be widely used in the clinical application.
Hashimoto thyroiditis combined with hypothyroidismWarming yang and strengthening spleenVitamin DImmune imbalance
万方数据
维普
