The effect of changes in estrogen concentration on the pregnancy outcome of frozen embryo transfer on the first day before transplantation
Objective To explore the impact of changes in estradiol(E2)concentration on pregnancy outcomes in patients un-dergoing frozen embryo transfer(FET)on the first day before transplantation.Methods A total of 360 infertile patients who received FET assisted pregnancy treatment with natural cycle(NC)and hormone replacement cycle(HRT)endometrial preparation regimens were se-lected as the study subjects.They were divided into three groups based on the changes in E2 concentration on the day before transplanta-tion.There were 244 cases in group A,with E2≥100 pg/mL on the day before transplantation,48 cases in group B,with E2＜100 pg/mL on the day before transplantation,and 68 cases in group C,with E2＜100 pg/mL+injection of human chorionic gonadotropin(HCG)on the day before transplantation.The general information,clinical characteristics,and pregnancy outcomes of three groups of patients were fol-lowed up and analyzed.Results There was no statistically significant difference in general information among the three groups(P＞0.05).In terms of pregnancy outcomes,the biochemical pregnancy rates of the three groups were 3.28％,2.08％,and 4.41％,respec-tively.The early miscarriage rates were 18.02％,22.22％and 13.79％,respectively.The multiple pregnancy rates were 10.81％,22.22％,and 3.44％,respectively,and the differences were not statistically significant(P＞0.05).The clinical pregnancy rates of the three groups were 45.49％,18.75％,and 42.65％,respectively.The live birth rates were 37.29％,14.58％,and 36.76％,respective-ly,with statistically significant differences(P＜0.05).In the NC protocol,the clinical pregnancy rates of the three groups were 49.18％,19.05％,and 47.73％,respectively,with statistically significant differences(P＜0.05).In the HRT regimen,the clinical pregnancy rates of the three groups of patients were 44.26％,18.52％,and 33.33％,respectively,with statistically significant differences(P＜0.05).Conclusion The change in estrogen(E2)concentration on the day before transplantation is significantly correlated with clinical pregnancy rate.For patients receiving FET with E2＜100 pg/mL,adding a small dose of human chorionic gonadotropin(HCG)during endometrial preparation can improve clinical pregnancy rate.NC and HRT regimens during FET endometrial preparation have no effect on pregnancy outcome.
万方数据
维普
