Objective To explore the impact of changes in estradiol(E2)concentration on pregnancy outcomes in patients un-dergoing frozen embryo transfer(FET)on the first day before transplantation.Methods A total of 360 infertile patients who received FET assisted pregnancy treatment with natural cycle(NC)and hormone replacement cycle(HRT)endometrial preparation regimens were se-lected as the study subjects.They were divided into three groups based on the changes in E2 concentration on the day before transplanta-tion.There were 244 cases in group A,with E2≥100 pg/mL on the day before transplantation,48 cases in group B,with E2＜100 pg/mL on the day before transplantation,and 68 cases in group C,with E2＜100 pg/mL+injection of human chorionic gonadotropin(HCG)on the day before transplantation.The general information,clinical characteristics,and pregnancy outcomes of three groups of patients were fol-lowed up and analyzed.Results There was no statistically significant difference in general information among the three groups(P＞0.05).In terms of pregnancy outcomes,the biochemical pregnancy rates of the three groups were 3.28％,2.08％,and 4.41％,respec-tively.The early miscarriage rates were 18.02％,22.22％and 13.79％,respectively.The multiple pregnancy rates were 10.81％,22.22％,and 3.44％,respectively,and the differences were not statistically significant(P＞0.05).The clinical pregnancy rates of the three groups were 45.49％,18.75％,and 42.65％,respectively.The live birth rates were 37.29％,14.58％,and 36.76％,respective-ly,with statistically significant differences(P＜0.05).In the NC protocol,the clinical pregnancy rates of the three groups were 49.18％,19.05％,and 47.73％,respectively,with statistically significant differences(P＜0.05).In the HRT regimen,the clinical pregnancy rates of the three groups of patients were 44.26％,18.52％,and 33.33％,respectively,with statistically significant differences(P＜0.05).Conclusion The change in estrogen(E2)concentration on the day before transplantation is significantly correlated with clinical pregnancy rate.For patients receiving FET with E2＜100 pg/mL,adding a small dose of human chorionic gonadotropin(HCG)during endometrial preparation can improve clinical pregnancy rate.NC and HRT regimens during FET endometrial preparation have no effect on pregnancy outcome.
维普
万方数据
