Study on the relationship between intracranial pressure amplitude monitoring and mannitol application in moderate to severe craniocerebral injuries and prognostic situation
Objective To explore the relationship between the monitoring of intracranial pressure amplitude and the application of mannitol and the prognosis of patients with moderate to severe craniocerebral injury.Methods A total of 80 patients with moderate to severe craniocerebral injury were selected and the patients were divided into two experimental group and control group.The control group was monitored solely by intracranial pressure monitoring,and mannitol was applied for patients with simple monitoring of intracranial pres-sure＞22 mmHg,while the observation group was monitored for mean intracranial pressure amplitude,and mannitol was applied for patients with mean intracranial pressure amplitude(MWA)＞5 mmHg.The total amount of mannitol,the duration of mannitol application,the inci-dence of mannitol-related complications,and the prognosis at three months after treatment were observed in the two groups.Results There was no statistically significant difference between the two groups in the comparison of general information such as gender,age,Glasgow Coma Scale(GCS)score,causes of injury,and site of hemorrhage(P＞0.05).The total amount of mannitol application and the time of mannitol application in the observation group were lower than those in control group,and the difference was statistically signifi-cant(P＜0.05).There was no significant difference between the two groups in acute renal failure,hypovolemia,arrhythmia and other com-plications(P＞0.05),but the incidence of hypertonic state,electrolyte disturbance,phlebitis and other complications in the observation group was significantly lower than that in the control group,the difference was statistically significant(P＜0.05).The good prognosis rate of observation group was 75.00％significantly higher than that of control group 52.50％,and the difference was statistically significant(P＜0.05).Conclusion The mean intracranial pressure amplitude(MWA)monitoring and treatment of mannitol in patients with moderate and severe craniocerebral injuries can improve the rate of good prognosis while reducing the total amount of mannitol applied,the duration of the application,and the mannitol-related complications,which has a certain clinical value.
万方数据
维普
