Correlation between pelvic dose and myelosuppression after postoperative radiotherapy for pelvic malignant tumors explored
Objective To study the correlation between pelvic radiation dose and myelosuppression in postoperative radiothera-py of pelvic malignancy,to provide a reference for the pelvic tolerance limits and to reduce the incidence of myelosuppression.Methods A retrospective analysis of 93 patients who underwent postoperative intensity modulated radiotherapy for pelvic malignancies was performed,and the occurrence of myelosuppression during treatment was observed,the influence of concurrent chemoradiotherapy and radiotherapy alone on myelosuppression were evaluated,and the correlation between myelosuppression and pelvic dose parameters such as mean dose of V45,V40,V35,V30,V25,V20,V15 and V10 was analyzed.Results In the whole group,the main manifestations of my-elosuppression after radiotherapy was a decrease in leukopenia and neutropenia.The incidence of myelosuppression in leukopenia was 95.70％,and the incidence of myelosuppression in neutrophils was 77.42％;Among 55 patients with concurrent chemoradiotherapy pa-tients,30 patients had grade 3～4 myelosuppression,mainly manifested as leukopenia and neutropenia.Compared with radiotherapy a-lone,the incidence of grade 3～4 myelosuppression was significantly higher(P＜0.05);Pelvic dose parameters V10 was associated with severe leukopenia decline(P＜0.05)and V15 was associated with severe neutrophil decline(P＜0.05).Conclusion Bone marrow suppression in patients undergoing postoperative radiotherapy for pelvic tumors is associated with low-dose irradiation of the pelvis,and concurrent postoperative radiotherapy is more likely to lead to bone marrow suppression than radiotherapy alone,so attention should be paid to protecting the pelvis and reducing the low-dose radiation area of the pelvis.
万方数据
维普
