The correlation of serum level of β2 microglobulin with mortality rate in maintenance hemodialysis patients
Objective To explore the correlations of serum β2-MG with all-cause mortality and cardiovascular and cerebro-vascular mortality of maintenance hemodialysis(MHD)patients.Methods 120 MHD patients were selected and the clinical data and biochemical results were collected before dialysis.The MHD patients were divided into three groups according to the predialysis serum β2-MG level,which were the low β2-MG group(β2-MG≤30 mg/L,n = 40),the medium β2-MG group(β2-MG 30～38.8 mg/L,n =40)andthehighβ2-MGgroup(β2-MG≥38.8 mg/L,n =40).The baseline data of the three groups were com-pared,Kaplan-meier survival analysis and Cox risk regression model were used to analyze the possible factors influencing the mortality in MHD patients.Results There were significant differences in dry weight,BMI,prevalence of diabetes,residual urine volume,dialysis age,phosphorus and eGFR among the three groups(P<0.05).Multipe stepwise linear regression analysis showed that serum β2-MG in patients with MHD was independenily negatively correlated with residual urine vdume(r =-3.475,P<0.05).Adjustedfor multivari-ate,Cox regression analysis showed that high levels of β2-MG were independent risk factors for mortality(HR = 1.039,95%CI:1.003～1.076,P<0.05)and cardiovascular and cerebrovascular mortality(HR =1.058,95%CI:1.015～1.102,P<0.05)in MHD patients.Compared with the middle-level β2-MG group,the survival rate of patients in the high-level β2-MG group was significant-ly reduced(HR =0.330,95%CI:0.126～0.861,P<0.05).Conclusion The serum β2-MG level is a significant predictor of mor-tality in MHD patients,suggesting that controlling serum β2-MG levels may improve outcomes.
Hemodialysisβ2-MicroglobulinAll-cause deathCardiovascular and cerebrovascular death
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NSTL
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