Effects of roxallistat and recombinant human erythropoietin on efficacy,serum microinflammatory markers and echocardiographic parameters in maintenance hemodialysis patients
Objective To observe the effects of rosalistat on the therapeutic effect,serum inflammatory index and echocardio-graphic parameters of patients with maintenance hemodialysis.Methods 75 patients were randomly divided into two groups:35 patients in rosalistat group took rosalrestat and 35 patients in recombinant human erythropoietin(rHuEPO)group was received regular subcutaneous injection of recombinant human erythropoietin.The basic parameters of patients between the two groups were compared.Hemoglobin(Hb),hematocrit(HCT),red blood cell count(RBC),homocysteine,β2 microglobulin,C-reactive protein and erythrocyte sedimenta-tion rate were compared between the two groups before and after treatment.At the same time,GE Vivid S6 color doppler ultrasound diag-nostic instrument was used to perform routine doppler echocardiography and two-dimensional echocardiography.All patients were fol-lowed up for at least 12 months.Results There were no significant differences in the basic data,dialysis time and primary disease be-tween the two groups(P>0.05).The efficacy of correcting renal anemia was observed in two groups of patients.After treatment,Hb,HCT and RBC significantly increased in both groups compared to before treatment(P<0.05).The levels of β2 microglobulin and C-reactive protein in both groups were significantly decreased before and after treatment(P<0.05).The level of β2 microglobulin in rosa-llistat group after treatment was significantly lower than that in rHuEPO group(P<0.05).After treatment,both groups of patients showed improvements in ventricular septal end diastolic thickness(IVsd)and left ventricular ejection fraction(LVEF)in cardiac ultra-sound compared to before treatment(P<0.05).There was a significant improvement in homocysteine(Hcy)in both groups before and after treatment(P<0.05).Linear correlation analysis showed that hemoglobin(Hb)was positively correlated with left ventricular ejec-tion fraction(LVEF)(r =0.1928,P<0.05).Conclusion Compared with rHuEPO,roxalstat can better correct anemia,reduce serum inflammatory indexes,improve chronic inflammatory status,and have a certain protective effect on cardiovascular related indexes.There-fore,roxalstat is safe in maintenance hemodialysis patients.
RoxallistatRecombinant human erythropoietinSerum inflammation indexHomocysteineEchocardiography
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