摘要
目的 探讨孕前女性维生素D和同型半胱氨酸水平现状及其影响因素,为改善孕前女性营养状况和预防不良妊娠结局提供科学依据.方法 选取进行孕前优生健康检查的405 名育龄妇女作为研究对象,采用二元logistic回归模型分析维生素D缺乏和高同型半胱氨酸血症的影响因素.结果 孕前女性维生素 D水平为13.04(10.30,16.48)ng/mL,同型半胱氨酸水平为 9.6(8.0,11.5)μmol/L.二元logistic回归结果显示,年龄<35岁(OR =2.491,95%CI:1.181～5.255)和夏季(OR =0.235,95%CI:0.066～0.834)是维生素D缺乏的影响因素.自费(OR =6.501,95%CI:2.501～16.900)和亚甲基四氢叶酸还原酶(MTHFR)检测中风险(OR =17.933,95%CI:3.916～82.124)是高同型半胱氨酸血症的影响因素.结论 银川市孕前女性维生素D缺乏率较高,同型半胱氨酸平均水平较高,应当重视孕前女性维生素D的补充和控制同型半胱氨酸水平,保障围产期健康.
Abstract
Objective To investigate the current status and influencing factors of vitamin D and homocysteine levels in pregesta-tional women.Methods A total of 405 women of childbearing age who underwent pre-pregnancy health examination were selected as the research subjects.Binary logistic regression model was used to analyze the influencing factors of vitamin D deficiency and hyperhomocys-teinemia.Results The levels of vitamin D and homocysteine were 13.04(10.30,16.48)ng/ml and 9.6(8.0,11.5)μmol/L before pregnancy.Binary logistic regression showed that:Vitamin D deficiency was associated with age<35(OR = 2.491,95%CI:1.181～5.255)and summer(OR =0.235,95%CI:0.066～0.834).Self-payment(OR =6.501,95%CI:2.501～16.900)and risk in MTHFR testing(OR =17.933,95%CI:3.916～82.124)were the influencing factors of hyperhomocysteinemia.Conclusion The rate of vitamin D deficiency and average level of homocysteine are high in women before pregnancy in Yinchuan city.It is necessary to pay attention to the supplementation of vitamin D and control of homocysteine level in women before pregnancy to ensure perinatal health.
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