The clinical significance of serum IL-6 level in evaluating the prognosis and efficacy of patients with primary immune thrombocytopenia
Objective To explore the impact of interleukin-6(IL-6)levels and on the prognostic efficacy of primary im-mune thrombocytopenia(ITP)patients.Methods 70 patients diagnosed with ITP were retrospectively analyzed.The clinical data were collected,and the serum IL-6 levels,platelet counts and bleeding scores were detected.According to the levels of serum IL-6,the pa-tients were divided into low level group(IL-6≤25 pg/mL),medium level group(25<IL-6≤35 pg/mL),and high level group(IL-6>35 pg/mL).The standardized treatment was used and all patients were followed up for three months.Laboratory tests and effi-cacy evaluations were analyzed.Multiple Cox regression analysis was used to analyze the correlation between IL-6 levels and patient prognosis indicators.Results Before treatment,there was no significant differences in platelet counts and bleeding scores among patients with different level of IL-6(P>0.05).After three months of treatment,the high IL-6 level group had lower platelet counts and high-er bleeding scores(P<0.05),while the low IL-6 level group showed the best prognosis(P<0.05).The age,disease duration,post-treatment bleeding score,platelet count,efficacy evaluation were correlated with IL-6 levels(P<0.05).Conclusion This study sug-gests a correlation between IL-6 and the prognosis of ITP patients,and high IL-6 levels may potentially indicate poor prognosis of ITP.The level of IL-6 is expected to be a potential biomarker for early evaluation of ITP patient prognosis,but further research and validation are still needed.
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