Analysis of the therapeutic effects of PVP/PKP combined with zoledronic acid on patients with osteoporosis compression fracture
Objective To evaluate the efficacy of percutaneous vertebroplasty(PVP)/balloon kyphoplasty(PKP)combined with zoledronic acid in the treatment of osteoporosis compression fractures and explore the impact on the incidence of subsequent fractures.Methods 110 patients with osteoporosis compression fractures were selected and equally divided into a study group and a control group.The patients in the control group received PVP/PKP treatment,while the patients in the study group received intravenous infusion of zole-dronic acid after the procedure.Cobb angle and anterior vertebral height were compared between the two groups before surgery,as well as at 1 week,3 months,and 6 months after surgery.Pain intensity was assessed by using the Visual Analog Scale(VAS),functional disability questionnaire,serum levels of bone alkaline phosphatase(BALP),type Ⅰ collagen C-terminal telopeptide(CTX-1),and vertebral bone mineral density(BMD)were measured.The occurrence of subsequent fractures was recorded.Results The study group showed signifi-cantly smaller Cobb angles and significantly higher anterior vertebral heights than the control group after the procedure(P<0.05).The study group had significantly lower VAS scores and functional disability index scores than the control group after surgery(P<0.05).Ad-ditionally,the study group had lower levels of BALP and CTX-1 and higher BMD at 3 months and 6 months after surgery compared to the control group(P<0.05).During the 6-month follow-up,the study group had a significantly lower incidence of subsequent fractures than the control group.Conclusion PVP/PKP combined with zoledronic acid treatment effectively relieves postoperative pain,improves vertebral function,regulates bone metabolism and increases bone density in osteoporosis compression fractures.Furthermore,this combina-tion therapy significantly reduces the incidence of subsequent fractures after surgery.Therefore,the combination of PVP/PKP and zoledron-ic acid may be a feasible treatment option that can improve the prognosis of compression fractures in osteoporosis.
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