Objective To evaluate the serum zinc levels in children with neonatal sepsis and explore the diagnostic value of neonatal septicemia.Methods A prospective investigation was carried out,with 52 cases of neonatal sepsis as the study group and 50 cases of healthy newborns as the control group.The enzyme-linked immunosorbent assay(ELISA)was used to monitor the levels of se-rum zinc of infants.The average level of serum zinc were compared between the two groups.Results There was no significant difference in general data between the tnog roups(P>0.05).The average level of serum zinc was(52.6±17.4)μg/dL,which was significantly lower than(83.2±21.4)μg/dL in the control group(P<0.05).There was no significant difference in serum zinc between the early onset sepsis(EOS)group(50.8±13.2)μg/dL and the late onset sepsis(LOS)group(53.4±14.4)μg/dL(P>0.05).The per-centage of leukocyte count,lymphocyte count,neutrophil count,and C-reactive protein in the group of neonatal sepsis were significantly higher than those in the control group(P<0.05).The level of serum zinc level was positively correlated with lymphocyte count(r =0.537,P<0.05)and was negative correlation with neutrophil count(r =0.544,P<0.05)in septicemia group.The area under ROC curve to predict neonatal sepsis was 0.812(P<0.05),which was weaker than CRP(AUC =0.865,P<0.05),but it was still val-uable in predicting diagnosis,with a sensitivity of 78%and a specificity of 76.9%.Conclusion Abnormal inflammatory response exists in neonates with serum zinc deficiency,which is related to the occurrence of neonatal sepsis.Serum zinc detection is valuable in predic-tion of neonatal sepsis.
NETL
NSTL
万方数据
