Clinical significance and diagnostic value of serum zinc detection in neonatal sepsis
Objective To evaluate the serum zinc levels in children with neonatal sepsis and explore the diagnostic value of neonatal septicemia.Methods A prospective investigation was carried out,with 52 cases of neonatal sepsis as the study group and 50 cases of healthy newborns as the control group.The enzyme-linked immunosorbent assay(ELISA)was used to monitor the levels of se-rum zinc of infants.The average level of serum zinc were compared between the two groups.Results There was no significant difference in general data between the tnog roups(P>0.05).The average level of serum zinc was(52.6±17.4)μg/dL,which was significantly lower than(83.2±21.4)μg/dL in the control group(P<0.05).There was no significant difference in serum zinc between the early onset sepsis(EOS)group(50.8±13.2)μg/dL and the late onset sepsis(LOS)group(53.4±14.4)μg/dL(P>0.05).The per-centage of leukocyte count,lymphocyte count,neutrophil count,and C-reactive protein in the group of neonatal sepsis were significantly higher than those in the control group(P<0.05).The level of serum zinc level was positively correlated with lymphocyte count(r =0.537,P<0.05)and was negative correlation with neutrophil count(r =0.544,P<0.05)in septicemia group.The area under ROC curve to predict neonatal sepsis was 0.812(P<0.05),which was weaker than CRP(AUC =0.865,P<0.05),but it was still val-uable in predicting diagnosis,with a sensitivity of 78%and a specificity of 76.9%.Conclusion Abnormal inflammatory response exists in neonates with serum zinc deficiency,which is related to the occurrence of neonatal sepsis.Serum zinc detection is valuable in predic-tion of neonatal sepsis.
NETL
NSTL
万方数据
