Identification efficacy of neutrophil/lymphocyte ratio,interleukin-6 and procalcitonin in identifying pathogenic bacteria in pulmonary infections
Objective To explore the differential efficacy of neutrophil/lymphocyte ratio(NLR),interleukin-6(IL-6),and procalcitonin(PCT)in identifying pathogenic bacteria in pulmonary infections.Methods A retrospective analysis of clinical data of 300 children with pulmonary infections was conducted.According to the different pathogens,they were divided into the viral infection group(n =158)and the bacterial infection group(n =142),another 140 healthy children during the same period were selected as the control group.The levels of NLR,IL-6,and PCT were detected and compared.ROC curves were drawn to analyze the differential efficacy of the above indicators for viral and bacterial infections.According to the identification results of bacterial Gram staining culture,children with bacterial infections were divided into Gram positive bacteria(G+bacteria)infection group(n =63 cases)and Gram negative bacte-ria(G-bacteria)infection group(n =79 cases),the levels of NLR,IL-6 and PCT were detected and compared and ROC curves were drawn to analyze the identification efficiency of the above indicators for G+bacteria and G-bacteria.Results The bacterial infection group was higher than the viral infection group,and the difference between the two groups was statistically significant(P<0.05).The levels of NLR,IL-6 and PCT were statistically significant in distinguishing viral and bacterial infections,with diagnostic AUCs of 0.913,0.875 and 0.957,respectively.Among 142 cases of bacterial infection in children,63 cases(68 strains)were caused by G+bac-teria and 79 cases(81 strains)were caused by G-bacteria.The level of NLR in the G+bacterial group was higher than that in the G-bacterial group.The levels of IL-6 and PCT were lower than those of the G-bacteria group,with statistically significant differences(P<0.05).The ROC results showed that the levels of NLR,IL-6 and PCT were statistically significant in distinguishing G+bacteri-al infection from G-bacterial infection,with diagnostic AUCs of 0.925,0.923 and 0.922,respectively.Conclusion NLR,IL-6 and PCT have certain clinical application value in the differential diagnosis of viral and bacterial infections,as well as G+and G-bacterial infections.
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