Correlation analysis between serum CA125,VEGF,whole blood NLR,MPV/PLT and prognosis of patients with epithelial ovarian cancer
Objective To analyze on serum cancer antigen 125(CA125),vascular endothelial growth factor(VEGF),whole blood neutrophil count/lymphocyte count(NLR),mean platelet volume/platelet count(MPV/PLT)and prognosis in patients with epi-thelial ovarian cancer(EOC).Methods 100 EOC patients were divided into survival group(n=65)and death group(n=35),and the demographic data and serum CA125,NLR,VE GF,and MPV/PLT levels were compared between two groups.The predictive value of CA125,NLR,VE GF,MPV/PLT for EOC prognosis were evaluated by using ROC curves,and the relationship between CA125,NLR,VE GF,and MPV/PLT and the prognosis of EOC were analyzed by using the COX regression analysis and K-M survival curves.Results The CA125,NLR,and VE GF levels were higher in the dead group than those in the surviving group,MPV/PLT was lower than those in surviving group(P＜0.05);ROC showed that AUC of CA125,NLR,VE GF,MPV/PLT and the combined predicted death were 0.786,0.697,0.875,0.811 and 0.877,respectively;The results showed significant differences in tumor metastasis,FIGO stage,CA125,NLR,VE GF,and MPV/PLT(P＜0.05);The tumor metastasis,FIGO stage were Ⅲ to Ⅳ,CA125 ≥ 38.22 U/mL,NLR≥2.89,VEGF≥981.45 ng/L,and MPV/PLT 0.042 were prognostic risk factors for EOC(P＜0.05);Follow-up for 2 years,the overall survival time of the patient was(17.75±4.71)months,the K-M analysis revealed that CA125＜38.22 U/ml,NLR＜2.89,VEGF＜981.45 ng/L and time of survival was significantly longer with MPV/PLT＞0.042(P＜0.05).Conclusion CA125,NLR,VEGF and decreased MPV/PLT are risk factors for poor prognosis of EOC,and CA125,NLR,VE GF,MPV/PLT are important for the prognosis of patients with EOC.
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