Study on the correlation between serum Ang-2 and HMGB1 and prognosis in patients with sepsis
Objective To study the correlation between the serum levels of angiopoietin-2(Ang-2)and high mobility group protein B1(HMGB1)with the condition and 28 day prognosis of sepsis patients.Methods A retrospective analysis was performed on the data of 41 patients with sepsis.According to the prognosis of the patients in 28 days,they were divided into survival group and death group,and according to the severity of the patients,they were divided into sepsis group and septic shock group.The general information of patients were recorded,and APACHE Ⅱ scores on the 1 st,3rd,5th,and 7th day of diagnosis were performed.The levels of Ang-2 and HMGB1 were measured.Results There was no significant difference in the general information between the survival group and the death group.The proportion of patients with septic shock(85.71％)and APACHE Ⅱ score(29.29±5.99)in the death group were signifi-cantly higher than those in the survival group(51.84％,24.96±5.84).There was no significant difference in serum Ang-2 and HMGB1 between the two groups.The level of HMGB1 on the 7th day was significantly correlated with the prognosis of patients with sep-sis,while the levels of HMGB1 and Ang-2 on the 1st,3rd,and 5th days were not correlated with the prognosis.The arithmetic mean of serum Ang-2 levels at the four time points was positively correlated with the arithmetic mean of the APACHE Ⅱ score,but the HMGB1 levels had no correlation with the APACHE Ⅱ score.The maximum area under the curve for the APACHE Ⅱ score,Ang-2 and HMGB1 levels on the 7th day of combination was 0.78,with a sensitivity of 92.9％and specificity of 59.3％.The area under the curve for pre-dicting prognosis by combining Ang-2 and HMGB1 levels on the 7th day was 0.71 the sensitivity and specificity were 92.9％and 55.6％.Conclusion The average serum levels of Ang-2 on the 1 st,3 rd,5 th,and 7 th day are positively correlated with the severity of the disease.The serum levels of Ang-2 and HMGB1 on the 7 th day have the highest sensitivity for assessing the prognosis of patients with sepsis,which are significantly higher than the evaluation value of a single index.
SepsisAngiopoietin-2High mobility group protein box-1Prognosis
NETL
NSTL
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