Effects of Yupingfeng granule combined with Montelukast sodium on immune function and serum levels of MCP-4 and MDC in children with chronic cough
Objective To explore the efficacy of Yupingfeng granules combined with Montelukast sodium in the treatment of children with chronic cough,and the effect on the immune function,macrophages chemotaxis protein-4(MCP-4),macrophage derived chemokine(MDC).Methods A total of 102 children with chronic cough were collected and the patients were divided into control group(n=51)and observation group(n=51)according to random envelope method.The control group was treated with Montelukast sodium,and the observation group was treated with Montelukast sodium combined with Yupingfeng granules.The clinical efficacy,pulmonary func-tion indicators peak expiratory flow(PEF),forced vital capacity(FVC),maximum voluntary ventilation(MVV),forced expiratory vol-ume in one second(FEV1),immune function indicators differentiation cluster 3(CD3+),differentiation cluster 8(CD8+),differentia-tion cluster 4(CD4+),CD4+/CD8+,serum inflammatory factors immunoglobulin E(IgE),MCP-4,interleukin-4(IL-4),MDC and eosinophil cationic protein(ECP)levels before and after treatment were compared between the two groups.Results After treat-ment,the total clinical effective rate of the observation group was 98.04％(50/51),which was higher than that of the control group 84.31％(43/51),the difference was statistically significant(P＜0.05).After treatment,the levels of FVC,FEV1,MVV and PEF in observation group were higher than those in control group,and the difference was statistically significant(P＜0.05).After treatment,the levels of CD4+/CD8+,CD4+and CD3+in the observation group were higher than those in the control group,and the level of CD8+was lower than that in the control group,the differences were statistically significant(P＜0.05).After treatment,the levels of IL-4,IgE,MCP-4,ECPand MDC in observation group were lower than those in control group(P＜0.05).Conclusion Yupingfeng granules combined with Montelukast sodium is effective in the treatment of children with chronic cough,which can inhibit the expression of inflam-matory factors,improve the immune function and improve the lung function.
Yupingfeng granulesMontelukast sodiumChronic coughImmune function
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