Study on the correlation between serum neurofilament light chain protein and cognitive impairment
Objective To investigate the correlation between serum neurofilament light chain protein(NFL)levels and cogni-tive impairment diseases,including mild cognitive impairment(MCI),Alzheimer's disease(AD),vascular dementia(VD).Methods According to the inclusion and exclusion criteria,the hospitalized patients diagnosed with cognitive impairment were collected and divided into MCI group(47 cases),AD group(46 cases),VD group(43 cases)and normal control group(45 cases).The AD group and VD group were divided into mild group and moderate to severe group based on the severity of the disease.All patients under-went cognitive function assessment and the serum NFL levels were detected.Results There was a significant statistical difference in ser-um NFL concentration among the four groups(P＜0.05).There was no significant difference in serum NFL concentration between MCI group and AD group(P＞0.05).The serum NFL concentration in VD group was significantly higher than the other three groups.There was a significant difference in serum NFL concentration between mild dementia and moderate to severe dementia patients in AD group(P＜0.05).There was a significant difference in serum NFL concentration between mild dementia and moderate to severe dementia pa-tients in VD group(P＜0.05).Conclusion The serum NFL level can be used as a peripheral blood biomarker for the early diagnosis and severity assessment of AD and VD.
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