The effects of propofol and sevoflurane on neurological function after traumatic brain injury in rats
Objective To observe the effects of propofol and sevoflurane on neurological function after traumatic brain injury(TBI)in rats.Methods SD rats were randomly divided into four groups(n=6):sham surgery group,injury group,injury+50 mg/kg propofol group(I+propofol),injury+2%sevoflurane group(I+sevoflurane).The TBI model was established using the improved Feeney method.Recorded the average arterial pressure and heart rate of each group of rats and measure the blood concentrations of neural specific serum biomarkers S-100β,neuron specific enolase(NSE),and myelin basic protein(MBP)in the serum.The level of oxida-tive stress was tested in brain tissue by detecting superoxide dismutase(SOD),catalase(CAT),and malondialdehyde(MDA)in brain tissue.Results There was no statistically significant difference in the effects of propofol and sevoflurane on MAP and HR during anes-thesia maintenance(P>0.05);Compared with the control group,the levels of S-100β,MBP and NSE in the serum of rats in the injury group were significantly increased.Propofol and sevoflurane significantly reduced the levels of S-100β,MBP,and NSE in rat serum 60 minutes after injury;Both propofol and sevoflurane reduced the expression of MDA in the brain tissue of TBI rats,while increasing the levels of SOD and CAT.Compared with the control group,the difference in MDA,SOD,and CAT in the I+sevoflurane group was statis-tically significant(P<0.05).Conclusion Propofol and sevoflurane have a protective effect on neurological function after traumatic brain injury in rats.Propofol and sevoflurane improve the prognosis of TBI rats by reducing reactive oxygen species.
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