Construction and evaluation of prognostic model for transmembrane protein family genes in hepatocellular carcinoma
Objective To explore the mechanisms and prognostic value of the Transmembrane protein(TMEM)family genes in liver cancer,and construct survival and prognosis prediction models for hepatocellular carcinoma(HCC).Methods TMEM family genes associated with the prognosis of HCC were analyzed and identified.The LASSO regression model was used to construct the prognostic pre-diction model,which was validated by an external cohort.The Nomogram was constructed based on the risk scores and clinical character-istics,and its predictive efficacy was verified.Results Seven TMEM family genes were included to construct the risk prediction model.HCC patients in the low-risk group had significantly better outcomes than those in the high-risk group.The Cox regression analysis showed that the risk score was an independent risk factor for the prognosis of liver cancer patients.In addition,Nomogram's prediction re-sults based on risk scores were well-fitting and useful for applications.Conclusion The prediction model based on the TMEM family genes can effectively predict the prognosis of HCC and offer a theoretical basis for the early identification of patients with poor prognosis of HCC.
万方数据
维普
