Intervention value of rTMS combined with resistance training in elderly patients with Parkinson's disease and the effect on non-motor symptoms
Objective To observe the intervention value of repetitive transcranial magnetic stimulation(rTMS)combined with resistance training in elderly patients with Parkinson's disease and the effect on non-motor symptoms.Methods 106 elderly patients with Parkinson's disease were enrolled in our hospital and randomly divided into two groups.All subjects were given conventional western medicine treatment,53 cases in the observation group were given rTMS combined with resistance exercise,and 53 cases in the control group were given rTMS treatment.The clinical efficacy,muscle strength,NMSS score and PDQ-39 score of Parkinson's disease patients were compared between the two groups.Results The curative effect of the observation group was better than that of the control group(P＜0.05).After treatment,the muscle strength of the ankle dorsiflexor,knee extensor and hip extensor were improved in both groups(P＜0.05),and the muscle strength of ankle dorsiflexor,knee extensor and hip extensor in the observation group was higher than that in the control group(P＜0.05).After treatment,NMSS scores of non-motor symptom frequency and severity were decreased in both groups(P＜0.05),and the NMSS scores of non-motor symptom frequency and severity in the observation group were lower than those in the control group(P＜0.05).At 4,8 and 12 weeks after treatment,PDQ-39 scores in both groups decreased gradually(P＜0.05).Aftert 4,8 and 12 weeks treatment,PDQ-39 scores in the observation group were lower than those in the control group(P＜0.05).Conclusion rTMS combined with anti-resistance exercise has good effects on improving the muscle strength,non-motor symptoms and quality of life in elderly patients with Parkinson's disease.
Old ageParkinson's diseaseRepeated transcranial magnetic stimulationResistance trainingNon-motor symptom
万方数据
维普
