Correlation analysis of serum inflammatory factors,homocysteine and echocardiography in cardiomyopathy in diabetic nephropathy patients on hemodialysis
Objective To analyze the correlation between serum inflammatory factors,homocysteine and echocardiography in maintenance hemodialysis patients and diabetic maintenance hemodialysis patients.Methods A total of 115 patients with maintenance hemodialysis were selected and divded them into maintenance hemodialysis patients with diabetes mellitus(MDD-DM)group(n=32)and maintenance hemodialysis patients without diabetes mellitus(MHD)group(n=83)detect their homocysteine,β2 microglobulin,C-reac-tive protein and erythrocyte sedimentation rate,respectively.Conventional Doppler echocardiography and two-dimensional echocardio-graphy were performed by GE Vivid S6 color Doppler ultrasound diagnostic instrument.Results The serum Hey level in the MDD-DM group was significantly higher than that in the MHD group.Serum β2-MG and CRP levels in MDD-DM group were significantly higher than those in MHD group(P＜0.05).Compared with the results of echocardiography between the two groups,the ventricular septal end diastolic thickness(IVsd),left ventricular end diastolic diameter(LVDd),right anterior ventricular wall thickness(RVAW),left anteri-or and posterior ventricle diameter(LVs)and left ventricular ejection fraction(LVEF)in the MDD-DM group were all higher than those in the MHD group,with statistical significance(P＜0.05).The linear correlation analysis showed that the left ventricular endolu-mental diameter(LVDd)was positively correlated with serum Hey level(r=0.1928,P＜0.05).Conclusion The serum Hey and β2 microglobulin of patients with hemodialysis are closely related to the lower ventricular hypertrophic and the left heart function,while ser-um Hey levels and β2 microglobulin levels are likely to play a very important role in the development of cardiovascular events and devel-opment in patients with blood dialysis.It is suggested that serum Hey and β2 microglobulin levels may help predict the severity of the left ventricular hypertrophic in patients with diabetes.
万方数据
维普
