首页|耐多药或利福平耐药肺结核与利福平敏感肺结核患者炎症因子表达对比分析

耐多药或利福平耐药肺结核与利福平敏感肺结核患者炎症因子表达对比分析

扫码查看
目的 分析耐多药或利福平耐药肺结核(MDR/RR-PTB)与利福平敏感肺结核(RS-PTB)患者炎症因子表达情况.方法 选取MDR/RR-PTB患者120例与RS-PTB患者120例,进行回顾性分析.结果 MDR/RR-PTB与RS-PTB2组内白细胞计数、中性粒细胞绝对值、血小板计数正常的患者占比均较高,血沉(ESR)增快患者占比较高,C反应蛋白(CRP)、降钙素原(PCT)升高的患者占比较高.2组患者的ESR、CRP、PCT、IL-6水平明显升高,均高于正常参考值.2组患者白细胞介素-6(IL-6)水平比较差异具有统计学意义(P<0.05),ESR、CRP、PCT水平比较差异均无统计学意义(P>0.05).结论 MDR/RR-PTB与RS-PTB2组患者外周血白细胞计数多为正常,ESR、CRP、PCT与IL-6水平均明显升高.MDR/RR-PTB组患者CRP水平高于RS-PTB组患者,MDR/RR-PTB组患者感染更严重.
Comparative analysis of inflammatory factor expression in patients with multi-drug-resistant/rifampicin-resistant pulmonary tuberculosis and rifampicin-sensitive pulmonary tuberculosis
Objective To analyze the expression of inflammatory factor levels in patients with multidrug/rifampicin resistant pulmonary tuberculosis(MDR/RR-PTB)and rifampicin sensitive pulmonary tuberculosis(RS-PTB).Methods 102 patients with MDR/RR-PTB and 170 patients with RS-PTB were selected for retrospective analysis.Results In the MDR/RR-PTB and RS-PTB2 groups,the percentage of patients with normal white blood cell counts,absolute neutrophil values,and platelet counts was higher,the percentage of patients with increased ESR was higher,and the percentage of patients with elevated CRP,PCT,and IL-6 was higher.The ESR,CRP,PCT,and IL-6 levels in both groups were significantly higher than the normal reference values.The comparison of the two groups of patients revealed that there was a statistical increase in the expression of CRP levels(P<0.05),and no statistically signif-icant increase in the expression of ESR,PCT,and IL-6(P>0.05).Conclusion The peripheral blood leukocyte counts of patients in the MDR/RR-PTB and RS-PTB groups are usually normal,and the expression of ESR,CRP,PCT and IL-6 are significantly higher.The expression of CRP in patients of MDR/RR-PTB group is higher than that in patients of RS-PTB group,and the infection is more serious in patients of MDR/RR-PTB group.

TuberculosisMulti-drug-resistant/Rifampicin-resistantRifampicin-sensitiveInflammatory factor

吕菊芬、温静、叶巧玲、付婷、段亚雄、王剑

展开 >

宁夏医科大学公共卫生学院,宁夏银川 750004

环境因素与慢性病控制重点实验室,宁夏银川 750004

宁夏回族自治区第四人民医院,宁夏银川 750025

肺结核 耐多药/利福平耐药 利福平敏感 炎症因子

2024

宁夏医学杂志
中华医学会宁夏分会

宁夏医学杂志

影响因子:0.706
ISSN:1001-5949
年,卷(期):2024.46(11)