The effect of urine volume on the blood concentration and intraperitoneal administration of vancomycin dose in patients with peritoneal dialysis associated peritonitis
Objective To explore the effect of 24-hour urine volume on the blood concentration and dosage of vancomycin in patients with peritoneal dialysis associated peritonitis.Methods Using a retrospective study method,a total 41 eligible patients with per-itoneal dialysis related peritonitis treated empirical or on target with vancomycin were screen.The patients were divided into 16 cases in no urine group(urine volume＜100 ml),15 cases in the oliguria group(100 mL≤urine volume＜400 mL),and 10 cases in the pres-ence of urine group(urine volume ≥400 mL)based on 24 h urine volume.The general data of the patients were recorded,24-hour u-rine volume,eGFR,vancomycin blood concentration,and the dose of vancomycin administered when the concentration reached the stand-ard were recorded.The effects of urine volume on vancomycin blood concentration and the dose of vancomycin administered were ana-lyzed.Results A total of 65 patients with peritoneal dialysis-associated peritonitis were collected,41 patients data were included in the study.The vancomycin blood concentrations(trough concentrations)in three groups of patients were(19.18±10.38)mg/L,(12.97±2.08)mg/L and(11.30±3.78)mg/L respectively.Compared with the group without urine Vancomycin blood concentration was signif-icantly lower in the oliguria group and the group with urine compared to the group without urine(P＜0.05).Vancomycin blood concen-tration was achieved at(4.27±1.09)mg/(kg·d-1)、(4.46±0.69)mg/(kg·d-1),(4.92±1.07)mg/(kg·d-1)in the three group.a higher dosage of vancomycin was administered at the vancomycin blood concentration level in the group with urine compared with that in the group without urine(P＜0.05).Pearson correlation analysis showed that 24 h urine volume was negatively correlated with vancomycin concentration(r=-0.462,P＜0.05).Conclusion 24-hour urine output could affect the blood concentration and dos-age of vancomycin in patients with peritoneal dialysis associated peritonitis.Residual renal function should be considered when using van-comycin in this population.
24-hour urine outputPeritoneal dialysis associated peritonitisVancomycinResidual kidney function
万方数据
维普
