Clinical characteristics of bile bacterial culture in acute cholecystitis
Objective To analyze the distribution characteristics and related risk factors of pathogens bacteria in the bile of pa-tients with acute cholecystitis.Methods Retrospective analysis was conducted to the bile specimens of 124 patients with acute cholecys-titis,and the clinical data and bacterial culture results of patients were recorded and analyzed.Results A total of 124 bile specimens were sent for examination,which 65 patients showed positive bacterial cultures,a positivity rate of 52.41％,79 strains were isolated.The majority were intestinal flora,including 31 strains of Enterococcus,21 strains of Escherichia coli,11 strains of Enterobacter,9 strains of Streptococcus pneumoniae,two strains of Klebsiella pneumoniae,two strains of Acinetobacter baumannii,two strains of Streptococcus,and one strain of Candida albicans.Drug sensitivity analysis of the main bacterial groups showed that Escherichia coli had a higher resistance rate to piperacillin,cefoxitin,and ampicillin/sulbactam;Enterococcus were more sensitive to tigecycline and vancomycin but had a higher resistance rate to erythromycin and ciprofloxacin;Enterobacter was generally sensitive to antibiotics.Multifactorial analysis identified that age ≥ 60 years,previous biliary surgery,persistent fever,and bilirubin were independent risk factors for positive bile cultures.Conclusion Pathogenic bacteria in the bile of acute cholecystitis are mostly enterococcus flora.Individualized use of antibiotics and at-tention to factors such as advanced age and previous biliary surgery can help improve the clinical management of acute cholecystitis.
万方数据
维普
