Application of thyroid function indexes in predicting gestational hypertension
Objective To investigate the relationship between thyroid function markers(TSH,FT3,FT4)during pregnancy and adverse pregnancy outcomes,and to assess the predictive capability of these indexes for gestational hypertension.Methods A retrospec-tive collection of data from 1 206 parturients was conducted.Difference analysis was used to preliminarily assess the association between various indicator and adverse pregnancy outcomes.Logistic regression analysis was used to identify adverse pregnancy outcome indicators affected by thyroid function,and R language software and plot nomograms were used to further explore the role of TSH,FT3 and FT4 in predicting hypertension during pregnancy.Results Among the adverse pregnancy outcomes,there was a statistically significant difference in TSH levels between women who underwent episiotomy and those who received medicated(P＜0.05).There was also a statistically significant difference in FT3 levels between women with and without hypertension(P＜0.05),while there was no statistically significant difference in FT4 levels among different pregnancy outcomes.Logistic regression analysis indicated that FT3(OR=1.46,P＜0.05),total cholesterol(OR=3.54,P＜0.05),and age(OR=1.18,P＜0.05)might be the risk factors for gestational hypertension,whereas high-density lipoprotein cholesterol(OR=0.25,P＜0.05)might be a protective factor.The linear plot analysis showed that the proba-bility of predicting gestational hypertension was from 0.05 to 0.8,with FT3,FT4,total cholesterol,and low-density lipoprotein as key predictive factors.Conclusion Thyroid function indexes FT3,TSH,and FT4 are closely related to adverse pregnancy outcomes and the predictive model composed of FT3,FT4 and TC combined with LDL-C can predict gestational hypertension.
万方数据
维普
