Application of multiple serum tumor markers combined with fecal occult blood detection in early diagnosis of colon cancer
Objective To study the application value of multiple serum tumor markers combined with fecal occult blood detec-tion in the early diagnosis of colon cancer.Methods 65 patients with early colon cancer were selected as colon cancer group,54 patients with colitis were selected as colitis group,and 50 healthy subjects who underwent physical examination during the same period were se-lected as control group.The serum tumor markers and fecal occult blood levels of patients were detected and compared,and the positive rate of single and combined indicators were statistically compared and analyzed.Meanwhile,the sensitivity,specificity and area under the curve(AUC)of tumor markers and occult blood detection for the diagnosis of colon cancer were analyzed and compared.Results The levels of tissue polypeptide antigen(TPA),carcinoembryonic antigen(CEA),Carbohydrate antigen 199(CA199),alpha-fetoprotein(AFP)and fecal occulted blood in colon cancer group were higher than those in colitis group and control group,and the difference be-tween groups was statistically significant(P＜0.05).The positive rate of all indicators in colon cancer group was higher than that in co-litis group and control group,and the positive rate of multiple tumor markers combined with fecal occult blood was higher than that of sin-gle indicator,the difference was statistically significant(P＜0.05).Logistic multivariate analysis showed that TPA,CEA,AFP,CA199 and fecal occult blood were all risk factors for colon cancer(P＜0.05).The sensitivity,specificity and AUC of the combined detection of tumor markers and fecal occult blood were higher than those of the single detection(P＜0.05).Conclusion TPA,CEA,AFP,CA199 and fecal occult blood show positive expression in patients with colon cancer,and multiple blood tumor markers combined with fecal occult blood detection can provide reference for the diagnosis of early colon cancer patients.
Early colon cancerTissue polypeptide antigenCarcinoembryonic antigenAlpha-fetoproteinCarbohydrate antigen 199Fecal occult bloodDiagnostic value
万方数据
维普
