Study on the effects of hydrochloride memantine on BDNF and BACE1 levels in patients with Alzheimer's disease
Objective To evaluate the efficacy of hydrochloride memantine in the treatment of patients with Alzheimer's disease(AD)and its effects on BDNF and BACE1 levels.Methods This study included 100 patients with Alzheimer's disease(AD)treated,who were randomly divided into an observation group(oral hydrochloride memantine)and a control group(oral donepezil),with 50 casesin each group.The patients in the observation group were treated with hydrochloride memantine,while those in the control group were treated with donepezil.After four months,the efficacy of the two groups of patients was evaluated using the Neuropsychiatric Inventory(NPI)and biomarkers(BDNF,BACE1).Results After treatment,the NPI score of the observation group was significantly lower than that of the control group,and the levels of BDNF and BACE1 were significantly better than those of the control group,with sta-tistically significant differences between the two groups(P＜0.05).Conclusion Hydrochloride memantine can effectively improve the psychiatric symptoms of patients with AD,positively regulate the levels of BDNF and BACE1,and has great potential value in the treatment of AD.
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