The relationship between the short-term efficacy of neoadjuvant chemotherapy and p53 gene positive in breast cancer
Objective To investigate the clinicopathological characteristics of patients with neoadjuvant chemotherapy(NAC),to explore the correlation between the short-term efficacy of neoadjuvant chemotherapy and the expression of p53 gene in breast cancer tissues,and explore the possibility ofp53 as a predictor of NAC.Methods The clinicopathological data of 115 patients with breast canc-er treated with neoadjuvant chemotherapy and the correlation between the short-term efficacy and the expression of p53 gene expression in breast cancer tissue were retrospectively analyzed.Results The effective rate of neoadjuvant chemotherapy in 115 patients with breast cancer was 94.8％.The expression of p53 gene was statistically different in clinical stage,axillary lymph node status,ER and PR status(P＜0.05).However,there were no significant difference in age,Her-2 status,Ki-67 expression(P＞0.05).In terms of molecular typing,the proportion of patients with positive p53 gene in triple-negative breast cancer was higher than that in patients with negative p53 gene(24％vs 13.8％),and the difference was statistically significant(P＜0.05).The proportion of p53 positive in Luminal A was significantly lower than that in p53 negative(18％vs 30.8％).The comparison of the efficacy of TAC and AC in 115 patients showed that the PR rate in the TAC group was higher than that in the AC group(28.6％vs 13.6％),and the difference was statistically significant(P＜0.05).When the p53 gene was positive,the PR rate in the TAC group was still higher than that in the AC group,and the difference was not statistically significant(P＞0.05).Conclusion NAC for breast cancer has high efficiency.The expression of p53 gene is closely related to the clinical stage,axillary lymph node status,ER and PR status of breast cancer.p53 gene positive patients may be more common in triple negative breast cancer,while p53 negative patients are more common in Luminal A type.So speculate that positive p53 gene expression is associated with poor prognosis of breast cancer.
Breast cancerNeoadjuvant chemotherapyp53 gene positivePredictive factors
万方数据
维普
