Effects of antiepileptic drugs on T lymphocyte subsets in adult patients with epilepsy
Objective To investigate the changes of T lymphocyte subsets in adult patients with epilepsy and the effects of an-tiepileptic drugs.Methods A total of 110 patients with epilepsy who were randomly divided into study group A 57 cases and study group B 53 cases.51 healthy people who selected the same physical examination as a control group.Group A was treated with carbamazepine combined with Magnesium Valproate,group B was given carbamazepine for treatment,and the treatment effect of patients in the study group and the changes of T lymphocyte subsets were compared.Results The levels of IgA and IgG in group A and group B were signifi-cantly lower than those in healthy control group.The levels of IgA and IgG in the study group were significantly higher after treatment,and the improvement of the study group was better than that of the control group(P＜0.05),there was no significant change in IgM levels be-fore and after treatment in the study group.There was no significant difference between the two groups(P＞0.05).Before treatment,CD3+,CD4+,CD4+/CD8+were significantly lower than those in the control group,CD8+was higher than the control group.After treat-ment,CD3+,CD4+,CD4+/CD8+were significantly increased in the study group,CD8+was significantly decreased,and the improvement in group A was better than that in group B(P＜0.05).There was no significant difference in the frequency of weekly seizures(P＞0.05).After treatment,the frequency of seizures was significantly lower in the two groups,and the degree of reduction in group A was more significant(P＜0.05).Conclusion The levels of T lymphocyte subsets in adults with epilepsy are significantly different from those in healthy people.The use of carbamazepine combined with Magnesium Valproate can improve the levels of IgA,IgG and other im-munoglobulins and CD3+,CD4+,CD8+,CD4+/CD8+,etc.The level of lymphocyte subsets also reduces the frequency of epileptic sei-zures in patients,and the effect is significant.
万方数据
维普
