Correlation between the number of antibiotic resistance gene sequences in mycoplasma pneumoniae and the effectiveness of azithromycin treatment in children with mycoplasma pneumonia
Objective To explore the relationship between the number of antibiotic resistance gene sequences in mycoplasma pneumoniae(MP)and the effectiveness of azithromycin treatment in children with mycoplasma pneumonia(MPP),and to provide important evidence for clinical precision therapy.Methods Clinical,laboratory,and imaging data from 142 children diagnosed with my-coplasma pneumoniae pneumonia who were hospitalized and selected in the study.LASSO regression was used to screen variables,and multivariate logistic regression analysis was conducted to identify independent risk factors related to the efficacy of azithromycin.The relationship between the number of MP resistance gene sequences and azithromycin efficacy was analyzed using smooth curve fitting and seg mented linear regression.Results LASSO regression analysis identified seven independent risk factors affecting azithromycin treat-ment efficacy,including hospitalization duration,age,number of MP resistance gene sequences,AM%in bronchoalveolar lavage fluid,urea,TBIL,and DBIL.The number of MP resistance gene sequences significantly influenced the efficacy of azithromycin.As the num-ber of MP resistance gene sequences increased,the effective treatment rate of azithromycin notably decreased.When the number of re-sistance gene sequences exceeded 10,198,effective rate of azithromycin treatment was less than 50%.Conclusion The number of MP resistance gene sequences is an important predictive factor for the effectiveness of azithromycin treatment.When the number of MP resist-ance sequences exceeds 10,198,alternative treatment options may be considered based on clinical needs.