首页|MP耐药基因序列数与MPP患儿阿奇霉素治疗效果的相关性研究

MP耐药基因序列数与MPP患儿阿奇霉素治疗效果的相关性研究

扫码查看
目的 探讨肺炎支原体(MP)耐药基因序列数与肺炎支原体肺炎患儿阿奇霉素治疗效果的关系.方法 选择142例肺炎支原体肺炎(MPP)患儿的临床、实验室及影像学等资料,采用LASSO回归筛选变量,多因素logistic回归分析发现阿奇霉素疗效相关独立危险因素,并通过平滑曲线拟合和分段线性回归分析探讨MP耐药基因序列数与阿奇霉素疗效的关系.结果 LASSO回归分析发现7个阿奇霉素治疗效果的独立危险因素,包括住院时间、年龄、MP耐药基因序列数、肺泡灌洗液肺泡巨噬细胞(AM%)、尿素、总胆红素(TBIL)和直接胆红素(DBIL).MP耐药基因序列数显著影响阿奇霉素的疗效.随着MP耐药基因序列数的增加,阿奇霉素的治疗有效率显著下降.当耐药基因序列数超过10 198时,阿奇霉素治疗有效率低于50%.结论 MP耐药基因序列数是阿奇霉素治疗效果的重要预测因素,当MP耐药序列数超过10 198时,依病情需要可换用其他治疗方案.
Correlation between the number of antibiotic resistance gene sequences in mycoplasma pneumoniae and the effectiveness of azithromycin treatment in children with mycoplasma pneumonia
Objective To explore the relationship between the number of antibiotic resistance gene sequences in mycoplasma pneumoniae(MP)and the effectiveness of azithromycin treatment in children with mycoplasma pneumonia(MPP),and to provide important evidence for clinical precision therapy.Methods Clinical,laboratory,and imaging data from 142 children diagnosed with my-coplasma pneumoniae pneumonia who were hospitalized and selected in the study.LASSO regression was used to screen variables,and multivariate logistic regression analysis was conducted to identify independent risk factors related to the efficacy of azithromycin.The relationship between the number of MP resistance gene sequences and azithromycin efficacy was analyzed using smooth curve fitting and seg mented linear regression.Results LASSO regression analysis identified seven independent risk factors affecting azithromycin treat-ment efficacy,including hospitalization duration,age,number of MP resistance gene sequences,AM%in bronchoalveolar lavage fluid,urea,TBIL,and DBIL.The number of MP resistance gene sequences significantly influenced the efficacy of azithromycin.As the num-ber of MP resistance gene sequences increased,the effective treatment rate of azithromycin notably decreased.When the number of re-sistance gene sequences exceeded 10,198,effective rate of azithromycin treatment was less than 50%.Conclusion The number of MP resistance gene sequences is an important predictive factor for the effectiveness of azithromycin treatment.When the number of MP resist-ance sequences exceeds 10,198,alternative treatment options may be considered based on clinical needs.

Mycoplasma pneumoniaMP resistance gene sequencesAzithromycinChildren

王军、王艳、李磊、金鹏飞

展开 >

宁夏银川市妇幼保健院普儿科,宁夏银川 750001

宁夏银川市妇幼保健院儿童呼吸科,宁夏银川 750001

肺炎支原体肺炎 MP耐药基因序列数 阿奇霉素 儿童

2024

宁夏医学杂志
中华医学会宁夏分会

宁夏医学杂志

影响因子:0.706
ISSN:1001-5949
年,卷(期):2024.46(12)