[Aims]This study aims to explore a new synthesis route of tetrachloroamilamide intermediate 2-amino-3,5-dichloro-N-methylbenzamide.[Methods]2-Amino-3,5-dichloro-N-methylbenzamide was synthesized from methyl 2-aminobenzoate by chlorination and amidation.[Results]The product was verified by nuclear magnetism and further synthesis of tetraclofenilamide,with purity of 98％and total yield of 92.7％.[Conclusions]The method has characteristics of simple process,cheap raw materials,less waste and high yield,which is suitable for industrial production.
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