Design,synthesis and insecticidal activity of benzothiazole derivatives
[Aims]The aim was to discover novel compounds with excellent insecticidal activities.[Methods]A series of benzothiazole derivatives were synthesized by the introduction of benzothiazole active substructures into metadiamide scaffolds.The compounds were prepared from 2-bromoaniline or 2-difluoromethoxyaniline through 8-step reactions including heptafluoroisopropylation,bromination and amidation,and their insecticidal aitivities were tested.[Results]The bioassay results in greenhouse showed that these target compounds exhibited excellent insecticidal activities against Mythimna separate and Plutella xylostella,especially compounds k1,k3 and k9 with mortality rates over 90％against the two pest insects at 5 mg/L.[Conclusions]Compounds k1,k3 and k9 could be candidates for further study or lead compounds for further structural optimization for discovery of compounds with high bioactivities.
万方数据
维普
