Design,synthesis and insecticidal activity of novel 1,2,3-thiadiazoles
[Aims]This study aims to find lead compounds with high activity.[Methods]A series of 1,2,3-thiadiazole compounds were designed by active substructure splicing method and synthesized.The structures of the target compounds were identified by 1H NMR and LC-MS.[Results]Most of the compounds exhibited good insecticidal activity against Plutella xylostella,Mythimna separata,Tetranychus cinnabarinus and Nilaparvata lugens.The mortality rates of compounds 1a,1b,1d,1e and 1h against P.xylostella and M.separata were all greater than 90％at 100 mg/L,the mortality rates of compounds 1a and 1e against T.cinnabarinus were greater than 90％at 100 mg/L,and the morta1ity rates of compounds 1a and 1e against N.lugens were greater than 90％at 400 mg/L.[Conclusions]This series of 1,2,3-thiadiazole compounds have certain insecticidal activities,novel structures and value for further research.
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