首页|新型三嗪酮硫醚衍生物的合成及生物活性

新型三嗪酮硫醚衍生物的合成及生物活性

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[目的]为了发现具有更高生物活性的新化合物.[方法]采用活性结构拼接法将硫醚片段引入吡蚜酮结构中,设计并合成了 10个三嗪酮硫醚衍生物,并对其进行了杀虫活性和抑菌活性测试.[结果]目标化合物的结构经1HNMR、13C NMR和HRMS分析确证.部分化合物在600 mg/L下对蚜虫和小菜蛾防效≥80%,在50 mg/L下对油菜菌核菌和苹果轮纹菌的抑菌率高于70%;化合物5j在10 mg/L下对蚊幼虫的致死率为70%.[结论]此类化合物具有一定的杀虫和杀菌效果,值得进一步研究.
Synthesis and biological activities of novel triazone thioether derivatives
[Aims]This study aims to discover novel compounds with high biological activities.[Methods]Thioether fragments were introduced into triazone by active structure splicing method to synthesize 10 triazone thioether derivatives.The insecticidal and fungicidal activities were tested.[Results]The structures of the target compounds were confirmed by 1H NMR,13C NMR and HRMS.Some compounds showed ≥80%control efficacy against Aphis craccivora and Plutella xylostella,showed more than 70%inhibition against Sclerotinia sclerotiorum and Physalospora piricol,the lethal rate of compound 5j against mosquito larvae was 70%.[Conclusions]The target compounds exhibit certain insecticidal and fungicidal activities and are worth further study.

triazonethioetherinsecticidal activityfungicidal activity

刘开思、蔡明江、庞晋纬、张思源、吕永康、杨岩、崔培培

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太原理工大学生物医学工程学院,山西晋中 030060

太原理工大学煤科学与技术教育部重点实验室,山西晋中 030060

太原理工大学艺术学院,山西晋中 030060

三嗪酮 硫醚 杀虫活性 抑菌活性

国家自然科学基金山西省基础研究计划

2200119020210302123180

2024

农药
沈阳化工研究院有限公司

农药

CSTPCD北大核心
影响因子:0.665
ISSN:1006-0413
年,卷(期):2024.63(2)
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