新型三嗪酮硫醚衍生物的合成及生物活性
Synthesis and biological activities of novel triazone thioether derivatives
刘开思 1蔡明江 1庞晋纬 1张思源 1吕永康 2杨岩 1崔培培3
作者信息
- 1. 太原理工大学生物医学工程学院,山西晋中 030060
- 2. 太原理工大学煤科学与技术教育部重点实验室,山西晋中 030060
- 3. 太原理工大学艺术学院,山西晋中 030060
- 折叠
摘要
[目的]为了发现具有更高生物活性的新化合物.[方法]采用活性结构拼接法将硫醚片段引入吡蚜酮结构中,设计并合成了 10个三嗪酮硫醚衍生物,并对其进行了杀虫活性和抑菌活性测试.[结果]目标化合物的结构经1HNMR、13C NMR和HRMS分析确证.部分化合物在600 mg/L下对蚜虫和小菜蛾防效≥80％,在50 mg/L下对油菜菌核菌和苹果轮纹菌的抑菌率高于70％;化合物5j在10 mg/L下对蚊幼虫的致死率为70％.[结论]此类化合物具有一定的杀虫和杀菌效果,值得进一步研究.
Abstract
[Aims]This study aims to discover novel compounds with high biological activities.[Methods]Thioether fragments were introduced into triazone by active structure splicing method to synthesize 10 triazone thioether derivatives.The insecticidal and fungicidal activities were tested.[Results]The structures of the target compounds were confirmed by 1H NMR,13C NMR and HRMS.Some compounds showed ≥80％control efficacy against Aphis craccivora and Plutella xylostella,showed more than 70％inhibition against Sclerotinia sclerotiorum and Physalospora piricol,the lethal rate of compound 5j against mosquito larvae was 70％.[Conclusions]The target compounds exhibit certain insecticidal and fungicidal activities and are worth further study.
关键词
三嗪酮/硫醚/杀虫活性/抑菌活性Key words
triazone/thioether/insecticidal activity/fungicidal activity引用本文复制引用
基金项目
国家自然科学基金(22001190)
山西省基础研究计划(20210302123180)
出版年
2024
NETL
NSTL
维普
万方数据