新型苯并(噁)唑类化合物的合成及杀虫活性
Synthesis and insecticidal activity of novel benzoxazole derivatives
徐靖博 1韩金龙 1常秀辉 1解喜山 1吴鸿飞1
作者信息
- 1. 沈阳中化农药化工研发有限公司新农药创制与开发国家重点实验室,农药国家工程研究中心,沈阳 110021
- 折叠
摘要
[目的]为了发现结构新颖的杀虫活性化合物.[方法]采用骨架跃迁策略设计合成了 15个新型苯并(噁)唑类化合物,并对其进行杀虫活性测试.[结果]初步的室内生测活性结果表明:在600mg/L质量浓度下,所有目标化合物对黏虫和小菜蛾均表现出较好的杀虫活性,致死率均为100％;对桃蚜和朱砂叶螨均没有表现出活性,致死率均为0.[结论]该类化合物可以作为先导化合物进行进一步结构优化研究.
Abstract
[Aims]This study aims to discover new compounds with insecticidal activities.[Methods]According to scaffold hopping method,15 novel benzoxazole derivatives were designed and synthesized,and their insecticidal activities were tested.[Results]Results of preliminary bioassay activities in green house showed that at 600 mg/L all the target compounds exhibited good insecticidal activities against Mythimna separata and Plutella xylostella,with mortality rates of 100％,but showed no activities against Myzus persicae and Tetranychus cinnabarinus,with mortality rates of 0,all at 600 mg/L.[Conclusions]The compounds could be lead compounds for further structural optimization study.
关键词
苯并(噁)唑/合成/杀虫活性Key words
benzoxazole/synthesis/insecticidal activity引用本文复制引用
出版年
2024
NETL
NSTL
万方数据