[Aims]The aim of this study is to discover a method to synthesize a rice field herbicide,fenoxasulfone.[Methods]Using 2,5-dichlorophenol as raw material,the intermediate 1,4-dichloro-2-(chloromethyl)-5-ethoxybenzene was synthesized by hydroxymethylation,substitution and chlorination,and then the target product was obtained by coupling and oxidation.[Results]Fenoxasulfone was synthesized by 7 steps of reactions,with purity of 98％and a total yield of 39.3％(caculated by 2,5-dichorophenol).[Conclusions]The synthetic methods of fenoxasulfone and its intermediates provided a reference for optimization of its synthetic process and synthesis research of its analogues.
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