Synthesis and insecticidal activity of N-alkoxy substituted diamide compounds
[Aims]The aim of this study is to discover novel insecticidal lead compound.[Methods]Introducing N-alkoxy structural fragments into broflanilide for the first time by the active substructure splicing method,23 novel diamide compounds never reported in the literature were designed and synthesized.[Results]The structures of the title compounds were confirmed by 1H NMR and HRMS.Some of them had excellent insecticidal activity against Plutella xylostella and Mythimna separata.Especially,compounds 1j,1s and 1t exhibited at least 90％mortality against P.xylostella and M.separata.[Conclusions]The compounds show good activity against lepidopteran pests.This study provides a useful reference for the structural enrichment and new lead discovery of diamide compounds.
NETL
NSTL
万方数据
