N-烷氧基取代双酰胺类化合物的合成及杀虫活性
Synthesis and insecticidal activity of N-alkoxy substituted diamide compounds
王奥运 1吴明慧 2吕亮 2相君成 2庞怀林 2彭鹏 2黄朋勉 1刘吉永2
作者信息
- 1. 长沙理工大学化学化工学院,长沙 410000
- 2. 南通泰禾化工股份有限公司,江苏南通 226407
- 折叠
摘要
[目的]为寻找新的杀虫先导化合物.[方法]采用活性亚结构拼接方法,首次将N-烷氧基结构片段引入溴虫氟苯双酰胺中,设计合成了 23个未见文献报道的结构新颖的双酰胺类化合物.[结果]目标化合物的结构均经过1H NMR和HRMS确证.部分化合物对小菜蛾和黏虫表现出了优异的防效,尤其是化合物1j、1s、1t在100 mg/L质量浓度下对小菜蛾和黏虫的致死率至少为90％.[结论]该类化合物表现出较好的杀鳞翅目害虫活性,本实验为双酰胺类化合物的结构丰富和新先导发现提供了有益的参考.
Abstract
[Aims]The aim of this study is to discover novel insecticidal lead compound.[Methods]Introducing N-alkoxy structural fragments into broflanilide for the first time by the active substructure splicing method,23 novel diamide compounds never reported in the literature were designed and synthesized.[Results]The structures of the title compounds were confirmed by 1H NMR and HRMS.Some of them had excellent insecticidal activity against Plutella xylostella and Mythimna separata.Especially,compounds 1j,1s and 1t exhibited at least 90％mortality against P.xylostella and M.separata.[Conclusions]The compounds show good activity against lepidopteran pests.This study provides a useful reference for the structural enrichment and new lead discovery of diamide compounds.
关键词
合成/双酰胺/杀虫活性/先导发现Key words
synthesis/diamide/insecticidal activity/lead discovery引用本文复制引用
出版年
2024
NETL
NSTL
万方数据