Synthesis and acaricidal activity of novel vinyl pyrazolyl acrylonitrile derivatives
[Aims]This study aims to discover novel compounds with acaricidal activity.[Methods]Using cyenopyrafen as lead compound,15 novel vinyl pyrazolyl acrylonitrile derivatives were designed and synthesized by introducing vinyl pyrazole into acrylonitrile structure,and their acaricidal activity were tested.[Results]Results of preliminary bioassay in green house showed that target compounds 6a-6h exhibited good acaricidal activities against Tetranychus cinnabarinus at 100 mg/L,with mortality rates of ≥99％.Compound 6g showed the best acaricidal activity,with a mortality rate of 88％at 10 mg/L.[Conclusions]When the H of the hydroxyl is substituted by alkylcarbonyl or alkoxycarbonyl,the resulting compounds exhibit good acaricidal activity.
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