苯甲酰基异氰酸酯中关键杂质对氟铃脲质量的影响
Effect of key impurities in benzoyl isocyanate on the quality of hexaflumuron
田俊杰 1刘宝宏 1张斌铨 1李凇宇 1张涛 1孙在臣1
作者信息
- 1. 德州绿霸精细化工有限公司,山东德州 253000;山东恒东生物科技有限公司,山东平原 253100
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摘要
[目的]对2,6-二氟苯甲酰基异氰酸酯中主要杂质进行定性分析,浅谈杂质的生成机理,优化车间生产工艺以达到减少或去除该杂质的目的.[方法]对2,6-二氟苯甲酰基异氰酸酯中的组分进行GC-MS和LC-MS分析.[结果]影响氟铃脲质量的2,6-二氟苯甲酰基异氰酸酯中关键杂质是N1,N2-双(2,6-二氟苯甲酰基)草酰胺(杂质A).[结论]优化合成工艺能有效减少2,6-二氟苯甲酰基异氰酸酯中的杂质A,改进工艺后杂质A降低了 97.8％,能够明显提升2,6-二氟苯甲酰基异氰酸酯的含量.
Abstract
[Aims]This study qualitative analyed the primary impurities in 2,6-difluorobenzoyl isocyanate,provided a concise overview of generation mechanism of the main impurity,and optimized the workshop production process to reduce or eliminate the impurities.[Methods]The components in 2,6-difluorobenzoyl isocyanate were analyzed using GC-MS or LC-MS.[Results]The primary impurity in 2,6-difluorobenzoyl isocyanate,significantly impacts the quality of hexaflumuron,was N1,N2-bis(2,6-difluorobenzoyl)oxalamide(A).[Conclusions]Optimization of the synthesis process leads to a remarkable reduction(by 97.8％)of impurity A,thereby significantly enhancing the quality of 2,6-difluorobenzoyl isocyanate.
关键词
氟铃脲/苯甲酰基异氰酸酯/杂质/GC-MS/LC-MSKey words
hexaflumuron/benzoyl isocyanate/impurity/GC-MS/LC-MS引用本文复制引用
出版年
2024
NETL
NSTL
万方数据