Effect of key impurities in benzoyl isocyanate on the quality of hexaflumuron
[Aims]This study qualitative analyed the primary impurities in 2,6-difluorobenzoyl isocyanate,provided a concise overview of generation mechanism of the main impurity,and optimized the workshop production process to reduce or eliminate the impurities.[Methods]The components in 2,6-difluorobenzoyl isocyanate were analyzed using GC-MS or LC-MS.[Results]The primary impurity in 2,6-difluorobenzoyl isocyanate,significantly impacts the quality of hexaflumuron,was N1,N2-bis(2,6-difluorobenzoyl)oxalamide(A).[Conclusions]Optimization of the synthesis process leads to a remarkable reduction(by 97.8％)of impurity A,thereby significantly enhancing the quality of 2,6-difluorobenzoyl isocyanate.
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