Comparison of residual 1-methyl-3-trifluoromethyl-4-hydroxymethyl-5-difluoromethoxy-1 H-pyrazole in different synthetic routes of pyroxasulfone
[Aims]This study aims to investigate the residues of 1-methyl-3-trifluoromethyl-4-hydroxymethyl-5-difluoromethoxy-1H-pyrazole(A2)found in different synthetic routes of pyroxasulfone.[Methods]Pyroxasulfone was synthesized via 3 different routes,among them routes 2 and 3 used intermediate A2,while route 1 did not.The resulting samples were analyzed for the presence of A2,and the potential sources of A2 residues were inferred.[Results]Intermediate A2 was found in all the three synthetic routes.In Route 1,A2 was speculated to be originated from side reaction of difluoromethylation of 4-(hydroxymethyl)-1-methy l-3-(trifluoromethyl)-1H-pyrazol-5-ol.In Routes 2 and 3,A2 was attributed to residual substrates from the synthesis process.[Conclusions]The intermediate A2 is found in samples from routes that do not use it,which suggests that the detection of A2 can't confirm the use of it in the synthetic pathway of pyroxasulfone.
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