摘要
假酶(pseudoenzyme)是一类没有催化活性的蛋白,其氨基酸序列与具有正常功能的酶家族相似,但因已被证实或预测的保守催化氨基酸的突变,从而缺乏催化活性.但假酶可能促进或抑制活性酶的活性、竞争活性酶的底物、调节信号通路,或者作为蛋白骨架形成蛋白复合体等.假酶在医学领域中研究较多,在植物领域中的研究尚显匮乏.最近的研究表明,假酶在植物生长发育和逆境胁迫响应方面发挥重要作用.本文从假酶的定义、鉴定方法和进化过程,以及假酶在植物中的生物学作用等方面介绍假酶,并讨论了假酶在植物发育调控中的潜在作用.本综述为利用假酶调控植物生长发育提供新的思路.
Abstract
Pseudoenzymes are proteins that have sequence homology with enzyme families but are proven or predicted to lack enzyme activity due to mutations in otherwise conserved catalytic amino acids.However,pseudoenzymes may be involved in promoting or inhibiting the activity of enzymes,competing with active enzymes for substrates,regulating signal pathways,or serving as protein scaffolds to form protein complex,etc.Although pseudoenzymes have been extensively studied in the medical field,research on the role of pseudoenzymes in plants is still scarce.Recent studies have shown that pseudoenzymes play important roles in stress response,growth,and development in plant.In this paper,multidimensional introduction to pseudoenzymes was provided,including their definition,identification methods,evolutionary processes,and biological roles in plants.Furthermore,the potential roles of pseudoenzymes in plant development regulation were also discussed.This review provides new insights for plant developmental regulation by using pesudoenzymes.
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